Researchers on the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), on the Tata Institute of Fundamental Research (TIFR)-Mumbai and TIFR-Hyderabad, have unveiled a complete understanding of the dangerous effects of Sugar-Sweetened Beverages (SSBs) on human well being, inflicting ailments equivalent to diabetes and weight problems.
Using a preclinical mouse mannequin that carefully mimics human consumption patterns, they confirmed {that a} common consumption of such beverages will lead to the onset of ailments, alter key physiological, molecular, and metabolic processes throughout varied organs.
In their study, the researchers together with Saptarnab Ganguly; Tandrika Chattopadhyay; Rubina Kazi; Souparno Das; Bhavisha Malik; Uthpala ML Padmapriya S. Iyer; Mohit Kashiv; Anshit Singh; Amita Ghadge; Shyam D. Nair; Mahendra S.Sonawane and Ullas Kolthur-Seetharam – who’s director of Centre for DNA Finger Printing & Diagnostics (CDFD), have proven how these sugar drinks drive weight problems, diabetes, and different metabolic problems.
Tissues response analysed underneath fed and fasted circumstances
The researchers gave mice 10% sucrose water to mimic persistent human sugar beverage consumption and later carried out an in depth analyses of molecular, mobile and metabolic responses in a number of tissues, together with the liver, muscular tissues and small gut, underneath fed and fasted circumstances.
Disproportionate absorption of glucose over different important vitamins
It was found that the small gut is a serious contributor to systemic glucose imbalances and an extreme sucrose consumption causes a “molecular addiction” within the intestinal lining. This leads to disproportionate absorption of glucose over different important vitamins equivalent to amino acids and fat. “The nutrient uptake imbalance disrupts energy metabolism and amplifies the dysfunction of other organs like the liver and muscles,” defined Dr. Ullas Kolthur-Seetharam.
The fed and fasting phases additionally demonstrated distinct anabolic and catabolic responses due to persistent sucrose consumption indicating how the nutrient allocation and useful resource mobilization contribute to systemic metabolic problems. While the liver doesn’t exhibit altered gene expression regardless of elevated glucose absorption, insulin resistance is triggered, exacerbating gluconeogenesis or glucose manufacturing that leads to metabolic imbalance, he stated.
The findings stress on the pressing want for insurance policies and consciousness campaigns to scale back consumption of sugar beverages, notably amongst weak populations. Identification of tissue-specific effects within the study has supplied a roadmap for creating focused therapies to fight the rising metabolic ailments linked to excessive sugar consumption, stated the researchers.
Strategies to mitigate metabolic effects of sugar-sweetened beverages
The study, performed in collaboration with TIFR Mumbai’s Mahendra Sonawane, has proposed potential therapeutic focusing on intestinal nutrient transport pathways and mitochondrial operate throughout tissues as methods to mitigate the metabolic effects of consumption of such beverages. The study has been revealed within the newest challenge ‘Journal of Nutritional Biochemistry’.
Published – March 21, 2025 04:43 pm IST
