IISc, startup develop magnetic nanobots to treat tooth sensitivity

BENGALURU: For thousands and thousands of individuals, the sudden, sharp ache of tooth sensitivity can flip a sip of chilly water right into a jolt. Now, researchers on the Indian Institute of Science (IISc), in collaboration with Bengaluru-based deep-tech startup Theranautilus, have engineered “CalBots” – magnetic nanobots that may seal the issue at its supply.As per IISc, CalBots are 400-nanometre particles loaded with a calcium silicate-based bioceramic formulation, designed to journey deep inside dentinal tubules, the tiny tunnels within the tooth that lead to nerve endings. Guided by an exterior magnetic discipline, the bots can penetrate up to 500 micrometres into the tubules and self-assemble into steady, cement-like plugs that recreate the tooth’s pure barrier. One utility, the group says, can supply lasting reduction.Dental hypersensitivity impacts almost one in 4 folks worldwide and happens when enamel erosion or gum recession exposes the dentine layer beneath, IISc mentioned. The tubules in dentine act as direct pathways to the nerves, which is why even delicate temperature modifications can set off ache. “We didn’t want to create a slightly better version of what’s already out there. We wanted a technology that solves a real problem in a way that no one’s attempted before,” Shanmukh Peddi, postdoctoral researcher at IISc’s Centre for Nano Science and Engineering (CeNSE) and co-founder of Theranautilus. The group used a very new class of bioceramic cement for the nanobots. While bioceramics are widespread in orthopaedics and dentistry, the formulation was designed particularly for hypersensitivity – to journey deeper and last more.To take a look at the method, they labored first on extracted human enamel. “On these samples, we applied CalBots under a magnetic field for 20 minutes, during which the bots sealed the dentinal tubules by forming deep, stable plugs – a result confirmed through high-resolution imaging,” Peddi mentioned.They then moved to animal trials, inducing sensitivity in mice and monitoring their consuming behaviour. “Healthy mice drank both cold and room temperature water equally. But sensitive mice completely avoided cold water. After treatment, they started drinking it again. We saw 100% behavioural recovery. That was a big moment for us,” he mentioned.The CalBots are made solely from supplies categorised as ‘Generally Recognised as Safe’ and handed toxicity assessments in mice. “This is a compelling demonstration of what nanorobotics can achieve, and how they could significantly impact future healthcare,” mentioned Ambarish Ghosh, professor at CeNSE and one of many examine’s corresponding authors.Debayan Dasgupta, former PhD scholar at CeNSE and co-founder of Theranautilus, sees this as a part of an even bigger technological shift. “We’ve created a regenerative, active nanomaterial – a step towards the kind of ‘tiny mechanical surgeons’ Richard Feynman once envisioned,” he mentioned.Peddi added: “This is something we’ve worked towards silently for years. And the fact that we’ve done it here, in India, makes us very happy.”